Bauer, John H. published the artcileEffects of diuretic and propranolol on plasma lipoprotein lipids, Formula: C13H8Cl2O4S, the main research area is diuretic propranolol plasma lipoprotein.
To define the effects of diuretics on plasma lipoproteins, experiments were performed in hypertensive subjects after placebo therapy, 4 wk after therapy with either hydrochlorothiazide (HCTZ)(I) [58-93-5] or ticrynafen (TCNF)(II) [40180-04-9], 3 mo after diuretic with propranolol (III) [525-66-6], and 1 mo after therapy with propranolol alone. Plasma lipoproteins were separated by ultracentrifugation and the lipid fractions isolated by extraction and silicic acid thin-layer chromatog. Plasma low-d. lipoprotein (LDL) total cholesterol fell and high-d. lipoprotein (HDL) total cholesterol rose in subjects receiving TCNF. TCNF had no effect on plasma very low-d. lipoprotein (VLDL) triglyceride or phospholipid. There were no significant changes in LDL or HDL total cholesterol in subjects on HCTZ. HCTZ tended to increase plasma VLDL triglyceride and phospholipid. The addition of propranolol to either diuretic had no effect on LDL or HDL total cholesterol but increased VLDL triglyceride, especially in subjects on HCTZ. Propranolol alone had no effect on any of the lipids measured.
Clinical Pharmacology & Therapeutics (St. Louis, MO, United States) published new progress about Lipoproteins Role: BIOL (Biological Study). 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Formula: C13H8Cl2O4S.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem