Sellman, R. published the artcileInduction of microsomal epoxide hydrolase by tienilic acid in the rat, Application In Synthesis of 40180-04-9, the main research area is tienilic acid microsome epoxide hydrolase.
The effects of tienilic acid (I) [40180-04-9] on drug-metabolizing enzymes in rat liver and kidneys were studied. Short-term treatment for 2 wk (450 mg/kg/day) increased the activity of microsomal epoxide hydrolase [9048-63-9] at least 2-fold in both rat liver and kidneys. The effect of tienilic acid on the activity of microsomal epoxide hydrolase in the liver was correlated with the dose at 20-450 mg/kg/day for 14 days. Tienilic acid had only marginal effects on cytochrome P-450-mediated monooxygenases. Tienilic acid caused an approx. 2-fold increase in glucuronide conjugation of 4-methylumbelliferone in the liver. No increase in the activity of rat hepatic microsomal UDP-glucuronosyltransferase toward o-aminophenol was detected. According to these results, tienilic acid can be regarded as one of the most specific inducers of microsomal epoxide hydrolase.
Journal of Applied Toxicology published new progress about Drug-metabolizing enzymes Role: PROC (Process). 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Application In Synthesis of 40180-04-9.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem