Tamuli, Kashyap J. published the artcileRecyclable Itaconic Acid with Water as Green Catalytic System: Synthesis of Substituted 1,5-Benzodiazepine Derivatives at Room Temperature, Synthetic Route of 1468-83-3, the main research area is benzodiazepine green preparation; phenylenediamine ketone cyclocondensation itaconic acid catalyst.
Herein, a water-mediated and metal-free mild protocol was described for the synthesis of 1,5-benzodiazepine derivatives I [R = i-Pr, Ph, 3-thienyl, etc.; R1 = H, 7-Me, 8-Me, 7-Cl, 8-Cl] via cyclocondensation reaction of o-phenylenediamines and ketones by using biodegradable naturally occurring itaconic acid (20 mol%) in 30 min with excellent yields. Major advantages of this method were reusable catalyst, metal free, toxic solvent free, tedious work-up free, no further purifications with column chromatog. and short reaction time.
ChemistrySelect published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Synthetic Route of 1468-83-3.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem