Sohail, Muhammad published the artcileDynamic Kinetic Asymmetric Transformation of Racemic Diastereomers: Diastereo- and Enantioconvergent Michael-Henry Reactions to Afford Spirooxindoles Bearing Furan-Fused Rings, Recommanded Product: 3-Acetylthiophene, the main research area is cyclohexanedione oxindole enone one pot diastereoselective reaction; oxindole dihydrobenzofuranone preparation nitrostyrene enantioselective Michael Henry tandem reaction; hydroxy nitro spirooxatricyclo dodecadiene indolinone preparation; Michael addition; asymmetric catalysis; dynamic kinetic asymmetric transformation; organocatalysis; spiro compounds.
Dynamic kinetic asym. transformation (DYKAT) reactions of racemic diastereomer mixtures that afforded the products as essentially single diastereomers with high enantioselectivities were described. DYKAT in the diastereo- and enantioselective synthesis of spirooxindoles bearing furan-fused rings was demonstrated. The starting materials of the DYKAT, dihydrobenzofuranone derivatives, were synthesized in racemic diastereomer mixtures, and these were transformed to the spirooxindole derivatives in high yields with high diastereo- and enantioselectivities through Michael-Henry cascade reactions with nitrostyrenes under organocatalytic conditions. In the reactions, regardless the stereochem. of the starting materials, all the four isomers were transformed to single diastereomers with high enantioselectivities and four new chiral centers were created.
Angewandte Chemie, International Edition published new progress about Diastereoselective synthesis. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem