On September 5, 1984, Ward, Robert William; Smith, Stephen Allan; Markwell, Roger Edward published a patent.Related Products of 16296-68-7 The title of the patent was Benzofuran- and benzothiophenecarboxylic acid derivatives. And the patent contained the following:
The title compounds I [X = O, S, SO, SO2, X1 = CH2; X = CH2, X1 = O; R = Ph, alkylphenyl, alkoxyphenyl, CF3C6H4, BrC6H4, ClC6H4, FC6H4, pyrrolyl, N-alkylpyrrolyl, furyl, thienyl, (un)substituted by Me, Cl, or Br; R1,R3 = H, alkyl; R2 = H, F, Cl, Br; R4 = H, alkyl] were prepared Thus, II (R2 = Br, R4 = R5 = H) was prepared by ring contraction of 6-bromo-4-chromanone with Tl(NO3)3, esterified, and subjected to Friedel-Crafts acylation with BzCl to give II (R2 = Br, R4 = Et, R5 = Bz) which was debrominated and saponified to II (R2 = R4 = H, R5 = Bz, III). At 5 mg/kg orally the phenylquinone writhing test in mice III gave analgesia in 90% of the animals. The experimental process involved the reaction of 5-Chlorobenzo[b]thiophene-3-carbaldehyde(cas: 16296-68-7).Related Products of 16296-68-7
The Article related to benzofurancarboxylate preparation analgesic, benzothiophenecarboxylate, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenothiophenes and other aspects.Related Products of 16296-68-7
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem