《Synthesis and application of α-carbonyl nitrile oxides》 was published in Organic Chemistry Frontiers in 2020. These research results belong to Guo, Xuanhua; Xu, Guangqiang; Zhou, Li; Yan, Huating; Hao, Xin-Qi; Wang, Qinggang. Synthetic Route of C6H6OS The article mentions the following:
An efficient and robust method to synthesize α-carbonyl nitrile oxide intermediates from ketones using tertbutyl nitrite was developed to afford two series of α-carbonyl isoxazoles I [R = Me, Ph, 4-MeC6H4, etc.] and α-carbonyl furoxans II [R1 = Ph, 2-furanyl, 2-naphthyl, etc.] in good to excellent yields. Excellent functional group tolerance and broad substrate scope were observed in this protocol. The practical utility of this protocol was demonstrated in gram-scale experiments and synthesis of some bioactive mols. In the experiment, the researchers used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Synthetic Route of C6H6OS)
1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Synthetic Route of C6H6OS
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem