In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Design, Synthesis, and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo, published in 2021-02-25, which mentions a compound: 3395-91-3, Name is Methyl 3-bromopropanoate, Molecular C4H7BrO2, HPLC of Formula: 3395-91-3.
In the present work, 103 novel acyclic nucleosides were designed, synthesized, and evaluated for their anticancer activities in vitro and in vivo. The structure-activity relationship (SAR) studies revealed that most target compounds inhibited the growth of colon cancer cells in vitro, of which (chloro-9H-purinyl)dodecanol I exhibited the most potent effect against the HCT-116 and SW480 cells with IC50 values of 0.89 and 1.15μM, resp. Furthermore, all of the (R)-configured acyclic nucleoside derivatives displayed more potent anticancer activity compared to their (S)-counterparts. Mechanistic studies revealed that compound I triggered apoptosis in the cancer cell lines via depolarization of the mitochondrial membrane and effectively inhibited colony formation. Importantly, I inhibited the growth of the SW480 xenograft in a mouse model with low systemic toxicity. These results indicated that acyclic nucleoside compounds are viable as potent and effective anticancer agents, and I may serve as a promising lead compound that merits further attention in future anticancer drug discovery.
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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem