So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Drogkaris, Vasileios; Northrop, Brian H. researched the compound: Methyl 3-bromopropanoate( cas:3395-91-3 ).Recommanded Product: Methyl 3-bromopropanoate.They published the article 《Byproducts formed During Thiol-Acrylate Reactions Promoted by Nucleophilic Aprotic Amines: Persistent or Reactive?》 about this compound( cas:3395-91-3 ) in ChemPlusChem. Keywords: thiol acrylate nucleophilic aprotic amine Michael reaction mechanism; click chemistry; density functional theory; nucleophiles; reaction mechanisms; thiol-Michael reactions. We’ll tell you more about this compound (cas:3395-91-3).
The nucleophile-initiated mechanism of thiol-Michael reactions naturally leads to the formation of undesired nucleophile byproducts. Three aza-Michael compounds representing nucleophile byproducts of thiol-acrylate reactions initiated by 4-dimethylaminopyridine (DMAP), 1-methylimidazole (MIM), and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) have been synthesized and their reactivity in the presence of thiolate has been investigated. Spectroscopic anal. shows that each nucleophile byproduct reacts with thiolate to produce a desired thiol-acrylate product along with liberated aprotic amines DMAP, MIM, or DBU, thus demonstrating that these byproducts are reactive rather than persistent. D. functional theor. computations support exptl. observations and predict that a β-elimination mechanism is favored for converting each nucleophile byproduct into a desired thiol-acrylate product, though an SN2 process can be competitive (i. e. within <2.5 kcal/mol) in less polar solvents. Here is just a brief introduction to this compound(3395-91-3)Recommanded Product: Methyl 3-bromopropanoate, more information about the compound(Methyl 3-bromopropanoate) is in the article, you can click the link below.
Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem