With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.
General procedure: To a solution of dithioacetals 3 or 4 (1 mmol) in dry THF (20 mL), cooled to -78 C, was added n-BuLi (1.4 mmol, 2.7 M solution in hexanes). The resulting mixture was stirred at this temperature for 30 min under argon atmosphere. Then, the corresponding aldehyde (Ar2-CHO) (1.1 mmol) in THF (10 mL) was added. The reaction mixture was stirred for 3 h at -78 C, warmed to room temperature and stirred for 4 h at this temperature. The mixture was diluted with ethyl acetate (25 mL), washed with a saturated aqueous solution of NH4Cl (30 mL), and then water (20 mL). The organic layer was dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The crude product was purified using a silica gel column chromatography with 10% acetone in petroleum ether as eluent., 3541-37-5
The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Czarnecka, Anna; Kowalska, Emilia; Bodzioch, Agnieszka; Skalik, Joanna; Koprowski, Marek; Owsianik, Krzysztof; Ba?czewski, Piotr; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 1229 – 1237;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem