With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17402-83-4,Benzo[b]thiophen-4-amine,as a common compound, the synthetic route is as follows.
General procedure: 2 ml of pyridine, 257 mg of N-[3-(dimethylamino)propyl]-N?-ethylcarbodiimide hydrochloride and 223 mg of benzo[B]thiophen-4-ylamine are added to a solution of 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of example 1, in 2 ml of N,N-dimethylformamide. The reaction mixture is stirred at ambient temperature for 15 hours, and then concentrated under reduced pressure. Water and ethyl acetate are added and the resulting mixture is thus stirred for 30 minutes. The precipitate formed is filtered off, and rinsed with water, ethyl ether and petroleum ether. The solid obtained is dried under vacuum. 262 mg of N-(1-benzothiophen-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the formed of an off-white solid
17402-83-4, As the paragraph descriping shows that 17402-83-4 is playing an increasingly important role.
Reference£º
Patent; Sanofi; Cali, Jean – Christophe; Sertar, Victor; Array, Frank; Carlson, Carl Andreas; Shio, Laulan; Thompson, Fabienne; (178 pag.)JP5680638; (2015); B2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem