With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95-15-8,Thianaphthene,as a common compound, the synthetic route is as follows.
95-15-8, To a solution of benzothiophene (1.0 g, 7.45 mmol) in THF (15 mL) was added t-BuLi (1.7 M, 4.8 mL, 1.1 eq.) at -780C (Scheme 11). After stirring at the same temperature for 30 minutes, a solution of I2 (2.08 g, 1.1 eq.) in THF (5 mL) was added dropwise. The mixture was warmed up gradually to room temperature and stirred for 2 hours. The reaction was diluted with ethyl acetate (20 mL). Excess I2 was reduced with 10% Na2S2O7 solution. The organic layer was washed with brine (2 x 10 mL), dried (MgStheta4) and concentrated under reduced pressure. Purification by flash column chromatography using hexane afforded 59 (1.60 g, 82%) as white solid. 1H NMR (CDCl3): 7.21-7.30 (m, 2H), 7.49 (s, IH), 7.7 (m, 2H).
The synthetic route of 95-15-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; QUEEN’S UNIVERSITY AT KINGSTON; WO2006/125324; (2006); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem