With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.
Pd(OAc)2 (0.025 mmol, 5.6 mg), PCy¡¤HBF4 (0.05 mmol,18.5 mg), 1a (0.25 mmol, 45.5 mg), and KOtBu (0.75 mmol,84 mg) were added to a Schlenk 8ask. And the mixture wasdissolved in 1 mL of toluene under a nitrogen atmosphere.*e reaction mixture was stirred at 110C for 24 h. *en,ethyl acetate was used to dissolve the mixtupe as much aspossible (except for inorganic salt). Celatom was used to;lter undissolved substance. After this, the solvent wasevaporated under vacuum and the mixture was analyzed byGC or puri;ed by column chromatography on silica gel(petpoleum ethep: ethyl aceta3te:1) to a5ord product 1cas a pale yellow solid. 2-phenylbenzo[b]thiophen-3(2H)-one 1,1-dioxide: C14H10O3S, pale yellow solid, 1H NMR(400 MHz, CDCl3) delta = 8.10 (dd, J 15.5, 7.8 Hz, 2H), 8.00(t, J 7.4 Hz, 1H), 7.87 (t, J 7.5 Hz, 1H), 7.50 – 7.41 (m,3H), 7.28 (dd, J 6.4, 3.1 Hz, 2H), 5.17 (s, 1H). ESI-HRMS:calcd for C14H10NaO3S+([M + Na+]) 281.0248, found281.0255.
1127-35-1, The synthetic route of 1127-35-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Liu, Hailong; Li, Wenjing; Fu, Haiyan; Chen, Hua; Li, Ruixiang; Li, Yu; Journal of Chemistry; vol. 2019; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem