With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.
5381-20-4, The intermediate 1- (3,4,5-trimethoxyphenyl) propan-1-one (448 mg, 2 mmol) and benzo [b] thiophene-3-carboxaldehyde (162.2 mg, 1 mmol) were dissolved in ethanol (8 mL ) solution,Stir at room temperature for 30min,Then add sodium hydroxide (3mL) until the reaction is complete, extract with CH2Cl2, wash with saturated sodium chloride solution, dry over anhydrous sodium sulfate, filter, spin dry the organic phase,The remaining crude product was recrystallized from ethanol to obtain the target compound (E)-3-(benzo[b]thiophen-3-yl)-2-methyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 206.1 mg, 56% yield.
The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Ningxia Medical University; Zhuang Chunlin; Shi Ying; Cong Hui; Zhang Wannian; Huang Jiaxuan; Yu Jianqiang; Xu Lijuan; Qu Zhuo; (21 pag.)CN110526854; (2019); A;,
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