5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5381-20-4, Tetrolic acid (42 mg, 0.5 mmol) was dissolved in methanol (2 mL) followed by addition of 2-iodo-4,5-dimethoxyphenethylamine (154 mg, 0.5 mmol), benzothiophene-3-carbaldehyde (81 mg, 0.5 mmol) and tert-butyl isocianide (42 mg, 0.5 mmol). The reaction mixture was stirred at rt for 48 h in a sealed screw cap vial. The resulting mixture was concentrated and subjected to the column chromatography on silicagel with hepthane-EtOAc (15-25%) as eluent to give the desired propargylamide 7i?. Mixture of rotamers ?9:1.17 Yield: 142 mg, 46%. 1H NMR (300 MHz, CDCl3): delta 8.02 (s, 0.9H), 7.93-7.82 (m, 1H), 7.80-7.62 (m, 1.1H), 7.46-7.31 (m, 2H), 7.03 (s, 0.9H), 6.91 (s, 0.1H), 6.42 (s, 0.1H), 6.38 (s, 0.9H), 6.31 (s, 0.1H), 6.23 (s, 0.9H), 6.06 (br s, 0.9H), 5.65 (br s, 0.1H), 3.92-3.49 (m, 7.9H), 3.45-3.28 (m, 0.1H), 2.90-2.65 (m, 1H), 2.29-2.08 (m, 1.3H), 2.03 (s, 2.7H), 1.41 (s, 0.9H), 1.38 (s, 8.1H); 13C NMR (75 MHz, CDCl3, major rotamer): delta 168.0, 155.8, 149.3, 148.0, 139.6, 138.5, 134.2, 129.3, 128.1, 125.2, 125.0, 123.0, 121.6, 121.4, 112.7, 90.3, 87.3, 73.7, 56.1, 56.0, 54.6, 51.8, 46.9, 40.3, 28.6, 5.0; HRMS (EI, [M]+) for C28H31IN2O4S calcd 618.1049, found 618.1040.
As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.
Reference£º
Article; Peshkov, Anatoly A.; Peshkov, Vsevolod A.; Pereshivko, Olga P.; Van Der Eycken, Erik V.; Tetrahedron; vol. 71; 23; (2015); p. 3863 – 3871;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem