With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20699-85-8,Methyl 5-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.
A mixture of 200 mg of methyl 5-aminobenzo[b]thiophene-2-carboxylate, 456 mg of trifluoroacetic anhydride,205 mg of triethylamine, and 10 ml of tetrahydrofuran was stirred for 24 hours at room temperature. Tert-butyl methylether was added to the reaction mixture, and the residue was washed with water, 1 M hydrochloric acid, an aqueoussaturated sodium hydrogen carbonate solution, and saturated saline, dried over magnesium sulfate, and concentratedunder reduced pressure. The residues were subjected to silica gel column chromatography, thereby obtaining 260 mgof methyl 5-(trifluoroacetylamino)benzo[b]thiophene-2-carboxylate.
20699-85-8, The synthetic route of 20699-85-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sumitomo Chemical Company Limited; MUKUMOTO, Fujio; TAMAKI, Hiroaki; KUSAKA, Shintaro; IWAKOSHI, Mitsuhiko; EP2926660; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem