With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.
Compound 1e (3.50 g, 23.46 mmol) and compound 1f (4.28 g, 23.46 mmol) were dissolved in 1,2-dichloroethane (250 mL),Trifluoroacetic acid (70 mg, 0.62 mmol) was added.The reaction was stirred at 50 C for 16 hours.The reaction solution was washed with saturated sodium bicarbonate solution (250 mL).Extract with dichloromethane (150 ml x 2).The organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated to dryness under reduced pressure.The mixture was purified by flash silica gel column chromatography (petroleum ether/ethyl acetate 100-60%) to give compound 1g (4.4 g, yellow solid, yield: 36%).
As the paragraph descriping shows that 1127-35-1 is playing an increasingly important role.
Reference£º
Patent; Zhengda Tianqing Pharmaceutical Group Co., Ltd.; Nanjing Mingde Drug Discovery Co., Ltd.; Yao Yuanshan; Chen Bin; Chen Yuan; Li Ao; Xu Ran; Huang Zhensheng; Tian Dongdong; Li Hongwei; Yang Chengshuai; Li Jian; Chen Shuhui; (35 pag.)CN107987066; (2018); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem