With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.360575-29-7,Methyl 4-bromobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.
After dissolving methyl 4-bromobenzo [b] thiophene-2-carboxylate (1 eq) in dimethylene glycol ether (DME), tetrakis (triphenylphosphine) palladium (0) (Pd (PPh3) 4, 0.02 eq), 4-fluorophenylboronic acid (1.1 eq) and 2M sodium carbonate (2M Na2CO3, 5 eq) The mixture was stirred at 60 DEG C for 5 hours. The reaction solution was cooled to room temperature, filtered through Celite, and the reaction filtrate was washed with water and EtOAc and extracted. A small amount of water in the organic layer was removed with anhydrous MgSO 4, the solvent was removed by distillation under reduced pressure, and the product was separated into a column to obtain the target compound in 92% yield., 360575-29-7
The synthetic route of 360575-29-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Chungnam National University Industry-Academic Cooperation Foundation; Kim, Uhn Hee; Yu, Sung Uhn; Kang, Nam Sook; Ku, Tae Sung; Park, Min Young; Kim, Young Hun; Bae, Hyun Ju; Kim, Jin Woo; In, Tae Gyu; Ju, Chun Gi; (44 pag.)KR101515985; (2015); B1;,
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