In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. The reactant in an enzyme-catalyzed reaction is called a substrate. Safety of Benzo[b]thiophen-4-amine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 17402-83-4, Name is Benzo[b]thiophen-4-amine, molecular formula is C8H7NS
Towards the development of an in vivo chemical probe for cyclin G associated kinase (GAK)
SGC-GAK-1 (1) is a potent, selective, cell-active chemical probe for cyclin G-associated kinase (GAK). However, 1 was rapidly metabolized in mouse liver microsomes by cytochrome P450-mediated oxidation, displaying rapid clearance in liver microsomes and in mice, which limited its utility in in vivo studies. Chemical modifications of 1 that improved metabolic stability, generally resulted in decreased GAK potency. The best analog in terms of GAK activity in cells was 6-bromo-N-(1H-indazol-6-yl)quinolin-4-amine (35) (IC50 = 1.4 muM), showing improved stability in liver microsomes while still maintaining a narrow spectrum activity across the kinome. As an alternative to scaold modifications we also explored the use of the broad-spectrum cytochrome P450 inhibitor 1-aminobenzotriazole (ABT) to decrease intrinsic clearance of aminoquinoline GAK inhibitors. Taken together, these approaches point towards the development of an in vivo chemical probe for the dark kinase GAK.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Safety of Benzo[b]thiophen-4-amine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 17402-83-4, in my other articles.
Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem