95-15-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95-15-8,Thianaphthene,as a common compound, the synthetic route is as follows.
a 2-Bromobenzothiophene 94.0 g (0.7 mol) of benzothiophene in 940 ml of absolute diethyl ether are initially taken at 20-30 C., and 332 g (0.77 mol) of a 15% strength solution of n-butyllithium in n-hexane are added dropwise in the course of 2 hours. After one hour, 127 g (0.799 mol) of bromine are added dropwise, also at 0 C., and stirring is continued for 2 hours. After working up was carried out in a conventional manner, 2-bromobenzothiophene is distilled off, finally at 1-1.2 mmHg and 84-86 C. Yield: 240 g (76%).
95-15-8 Thianaphthene 7221, abenzothiophene compound, is more and more widely used in various fields.
Reference£º
Patent; BASF Aktiengesellschaft; US5110829; (1992); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem