With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4923-87-9,5-Bromobenzothiophene,as a common compound, the synthetic route is as follows.
To the stirring solution of compoundS2(12.0 g, 56.3 mmol) in THF (300 mL) was added isopropylmagnesium chloride (150 mL, 1.3 M in THF) drop wise at 0oC under nitrogen. The resulting mixture was stirred at rt overnight. To the reaction mixture was addedN,N-dimethylformamide (30.0 mL) drop wise. The resulting solution was stirred for 30 min at rt. The reaction was then quenched by the addition of H2O (500 mL). The mixture was extracted with ethyl acetate (3 x 500 mL), and the organic layers were combined and concentrated under vacuum. The residue was applied onto a silica gel column, eluting with ethyl acetate/petroleum ether (1:50 v/v). CompoundS2was obtained as a yellow solid (6.90 g, 68 % yield).1H NMR (400 MHz, Chloroform-d) delta 10.07 (s, 1H), 8.25 (s, 1H), 7.95 (d,J= 8.6 Hz, 1H), 7.83 (d,J= 8.6 Hz, 1H), 7.53 (d,J= 5.1 Hz, 1H), 7.43 (d,J= 6.1 Hz, 1H).
4923-87-9, As the paragraph descriping shows that 4923-87-9 is playing an increasingly important role.
Reference£º
Article; Huang, Hui; Winters, Michael P.; Meegalla, Sanath K.; Arnoult, Eric; Paul Lee; Zhao, Shuyuan; Martin, Tonya; Rady, Brian; Liu, Jianying; Towers, Meghan; Otieno, Monicah; Xu, Fran; Lim, Heng Keang; Silva, Jose; Pocai, Alessandro; Player, Mark R.; Bioorganic and Medicinal Chemistry Letters; vol. 28; 3; (2018); p. 429 – 436;,
Benzothiophene – Wikipedia
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