In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 35212-85-2, name is Methyl 3-aminobenzo[b]thiophene-2-carboxylate, introducing its new discovery. Quality Control of Methyl 3-aminobenzo[b]thiophene-2-carboxylate
Synthesis of the HIF-2alpha translation inhibitor compound 76 via a Japp-Klingemann coupling
The Iliopoulos laboratory previously reported the discovery of compound 76, a small molecule HIF2alpha inhibitor. HIF2alpha activation is known to play a critical role in both von Hippel-Lindau (VHL) disease-related tumors and sporadic renal cell carcinoma (RCC). We required a facile and scalable synthetic route to confirm the structure, to investigate the biological properties of compound 76, and to perform structure activity relationship optimization studies. Herein, we report the straightforward synthesis of compound 76 and a preliminary investigation into the scope of the methods developed.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 35212-85-2, and how the biochemistry of the body works.Quality Control of Methyl 3-aminobenzo[b]thiophene-2-carboxylate
Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem