4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 5-bromobenzo [b] thiophene (8.5 g, 40 mmoL) in 1, 4-dioxane (150 mL) was added 4, 4, 5, 5-tetramethyl-2- (1, 4-dioxaspiro [4.5] dec-7-en-8-yl) -1, 3, 2-dioxaborolane (10.6 g, 40 mmol), Pd (dppf) Cl2 (4.4 g, 6 mmol) and Cs2CO3 (19.5 g, 60 mmol) and the mixture was heated at 80 for 2 hours. Then filter off the solid, the filtrate was evaporated under reduced pressure and the residue was purified by column chromatography (PE: EA=25: 1) to give product as yellow solid (6.6 g in 61% yield). 1HNMR (400 MHz, DMSO-d6) deltaH 7.92 (d, J= 8.8 Hz, 1H), 7.89 (s, 1H), 7.74 (d, J= 5.2 Hz, 1H), 7.46 (dd, J = 8.8 Hz, 1.6 Hz, 1H), 7.43 (d, J = 5.6 Hz, 1H), 6.09 (t, J = 3.6 Hz 1H), 3.93 (s, 4H), 2.63 (t, J= 5.6 Hz, 2H), 2.40 (s, 2H), and 1.85 (t, J= 6.4 Hz, 2H). [M+H] += 273.0.
4923-87-9 5-Bromobenzothiophene 2776578, abenzothiophene compound, is more and more widely used in various.
Reference£º
Patent; BEIGENE, LTD.; WANG, Hexiang; GUO, Yunhang; REN, Bo; WANG, Zhiwei; ZHANG, Guoliang; ZHOU, Changyou; (353 pag.)WO2018/54365; (2018); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem