34761-09-6, Ethyl 3-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 1I (R)-3-[2-[3-(2-Methoxyphenyl)-1-pyrrolidinyl]ethyl]-[1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione Monohydrochloride A solution of Example 1H (664 mg, 3 mmol) and triethylamine (0.84 mL, 6 mmol) in THF (20 mL) was treated with 1.93M phosgene in toluene (1.7 mL, 3.3 mmol), stirred for 2 hours, treated with a solution of Example 1G (330 mg, 1.5 mmol) in toluene (50 mL), stirred for 4 hours, treated with 5% aqueous sodium bicarbonate and extracted with methylene chloride. The extract was dried (Na2 SO4) and concentrated, and the residue was dissolved in toluene, refluxed for 18 hours, cooled and filtered. The filtrate was treated with ethanol saturated with HCl, triturated with diethyl ether and filtered to provide the title compound. mp 169-173 C.; [alpha]D23 =+3.7 (c 0.004, MeOH); 1 H NMR (300 MHz, CD3 OD) delta 2.19-2.55 (m, 2H), 3.30 (m, 1H), 3.55 (m, 1H), 3.67 (t, 3H), 3.78 (m, 1H), 3.90 (s, 3H), 4.00 (m, 1H), 4.16 (q, 1H), 4.48 (t, 2H), 6.98 (m, 2H), 7.28 (m, 2H), 7.60 (m, 2H), 8.01 (d, 1H), 8.21 (d, 1H); MS (DCI/NH3) m/e 422 (M+H)+; Anal. calc’d for C23 H23 N3 O3 S.1.0 HCl: C, 60.32, H, 5.28, N, 9.18,. Found: C, 60.82, H, 5.36, N, 9.22.
As the paragraph descriping shows that 34761-09-6 is playing an increasingly important role.
Reference£º
Patent; Abbott Laboratories; US6133275; (2000); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem