Passerini-type reaction of boronic acids enables α-hydroxyketones synthesis was written by Yang, Kai;Zhang, Feng;Fang, Tongchang;Li, Chaokun;Li, Wangyang;Song, Qiuling. And the article was included in Nature Communications in 2021.COA of Formula: C8H7BO2S This article mentions the following:
Multicomponent reactions (MCRs) facilitate the rapid and diverse construction of mol. scaffolds with modularity and step economy. In this work, engagement of boronic acids as carbon nucleophiles culminates in a Passerini-type three-component coupling reaction towards the synthesis of an expanded inventory of α-hydroxyketones with skeletal diversity. In addition to the appealing features of MCRs, this protocol portrays good functional group tolerance, broad substrate scope under mild conditions and operational simplicity. The utility of this chem. is further demonstrated by amenable modifications of bioactive products and pharmaceuticals as well as in the functionalization of products to useful compounds In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6COA of Formula: C8H7BO2S).
Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is also used in the manufacturing of dyes such as thioindigo.COA of Formula: C8H7BO2S
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem