Optimization of synthesis process of 1,3,2-dioxathiolane 2,2-dioxide was written by Wang, Peihong;Zhang, Nan;Zhou, Baoqiang;Gao, Ruichang. And the article was included in Huagong Jinzhan in 2016.Safety of 1,3,2-Dioxathiolane 2,2-dioxide This article mentions the following:
1,3,2-Dioxathiolane 2,2-dioxide is synthesized from ethylene glycol and thionyl chloride in the presence of ruthenium trichloride heterogeneous catalyst and oxidant, and characterized by 1H NMR and IR. The effects of different oxidants, molar ratio of raw materials, reaction temperature, reaction time, oxidant dosage and catalyst dosage on the yield of target product are investigated. The optimal reaction conditions contain sodium periodate as oxidant, thionyl chloride:ethylene glycol molar ratio of 1.2:1, sodium periodate:ethylene glycol mass ratio of 3:1, catalyst:ethylene glycol mass ratio of 0.002:1, reaction temperature of 40°C and reaction time of 60 min. Under the optimal reaction conditions, the yield of target product reaches 81.25%. The synthesis process has advantages of fewer byproducts, lower toxicity and higher yield, and is more valuable in practical application. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Safety of 1,3,2-Dioxathiolane 2,2-dioxide).
1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Safety of 1,3,2-Dioxathiolane 2,2-dioxide
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem