A convenient transformation of alkynes to α-hydroxy-α-CF3-γ-ketoester derivatives via H3PO4-catalyzed tandem hydration and aldol condensation was written by Wang, Jiali;Yao, Jun;Jia, Chunqi;Hu, Dandan;Chen, Yun-Hua;Song, Jinyu;Zhang, Jun-Qi;Ren, Hongjun. And the article was included in Green Chemistry in 2022.Safety of 2-Ethynylthiophene This article mentions the following:
A robust metal-free catalytic strategy for the rapid construction of the valuable α-hydroxy-α-CF3-γ-ketoester skeleton with cheap and easily available stock chems. (alkynes and trifluoropyruvate) as the starting material was described. This protocol showed very good functional group tolerance and was easily scaled up. Importantly, compared with transition metal-catalyzed methods, this strategy was made more environmentally friendly by employing a catalytic amount of H3PO4 as the catalyst. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Safety of 2-Ethynylthiophene).
2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Safety of 2-Ethynylthiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem