Pyrrolo[1,2-a]quinoxalines from chalcones: An alternate route was written by Togiti, Uday Kumar;Shukla, Adarash Kumar;Bhattacharya, Anupam. And the article was included in Tetrahedron Letters in 2021.Application In Synthesis of 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one This article mentions the following:
The synthesis of 2,4-disubstituted pyrrolo[1,2-a]quinoxalines from chalcones is reported. The key steps used are polyphosphoric acid (PPA) assisted acyl rearrangement of the pyrrole ring and Fe catalyzed reduction-cyclization leading to 2,4-disubstituted pyrrolo[1,2-a]quinoxalines. Despite the utilization of comparatively unreactive aromatic ketones, modest to good yields were obtained. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Application In Synthesis of 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one).
3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application In Synthesis of 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem