Day: February 27, 2023

All solid state (ASS) polymeric membrane sensor (PMS) for the monitoring of nanomolar nickel concentration was written by Ganjali, Mohammad Reza;Alahdadi, Iraj;Aghazadeh, Mustafa;Pourbasheer, Eslam. And the article was included in International Journal of Electrochemical Science in 2015.Computed Properties of C26H26N2O2S This article mentions the following:

A nickel(II) selective all-solid-state PVC membrane sensor (ASS-PMS) has been designed and constructed for the monitoring of nanomolar nickel(II) concentrations in various samples. The applicability of the sensor to real samples was proved through its use for the anal. of the target ion in waste water samples. The all solid state support and transducer was build through coating a nickel wire with a composite of graphite powder and an epoxy resin, and next it was coated with a nickel selective PVC membrane, with the optimal composition of 33% of PVC, 57% of Nitrobenzene, 2% RTIL (1-n-butyl-3-methylimidazolium hexafluorophosphate), 3% of KpClTPB, and 5% of ionophore L. The potential response of the ASS-PMS change with the concentration of the target ion at a slope of 29.5 ± 0.3 mV/decade, which is indicative of a Nernstian behavior, and was linear in the concentration range of 1.0 × 10-8 to 1.0 × 10-3 mol L-1 of the nickel(II), reaching a lower detection limit as low as 5.0 × 10-9 mol L-1. The response of the ASS-PMS was found to be almost independent from interference from different conventional ionic species. The ASS-PMS was successfully applied to the potentiometric determination of nickel(II) concentrations in ions electroplating waste water samples. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5Computed Properties of C26H26N2O2S).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Computed Properties of C26H26N2O2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Pyrrolo[1,2-a]quinoxalines from chalcones: An alternate route was written by Togiti, Uday Kumar;Shukla, Adarash Kumar;Bhattacharya, Anupam. And the article was included in Tetrahedron Letters in 2021.Application In Synthesis of 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one This article mentions the following:

The synthesis of 2,4-disubstituted pyrrolo[1,2-a]quinoxalines from chalcones is reported. The key steps used are polyphosphoric acid (PPA) assisted acyl rearrangement of the pyrrole ring and Fe catalyzed reduction-cyclization leading to 2,4-disubstituted pyrrolo[1,2-a]quinoxalines. Despite the utilization of comparatively unreactive aromatic ketones, modest to good yields were obtained. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Application In Synthesis of 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application In Synthesis of 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases was written by Bhushan, Bhaskar;Erdmann, Alexandre;Zhang, Yijia;Belle, Roman;Johannson, Catrine;Oppermann, Udo;Hopkinson, Richard J.;Schofield, Christopher J.;Kawamura, Akane. And the article was included in Bioorganic & Medicinal Chemistry in 2018.Recommanded Product: 1195-14-8 This article mentions the following:

Plant homeodomain (PHD) finger containing proteins are important epigenetic regulators and are of interest as potential drug targets. Inspired by the amiodarone derivatives reported to inhibit the PHD finger 3 of KDM5A (KDM5A(PHD3)), a set of compounds were synthesized. Amiodarone and its derivatives were observed to weakly disrupt the interactions of a histone H3K4me3 peptide with KDM5A(PHD3). Selected amiodarone derivatives inhibited catalysis of KDM5A, but in a PHD-finger independent manner. Amiodarone derivatives also bind to H3K4me3-binding PHD-fingers from the KDM7 subfamily. Further work is required to develop potent and selective PHD finger inhibitors. In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8Recommanded Product: 1195-14-8).

2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Recommanded Product: 1195-14-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1) was written by Getlik, Matthaus;Smil, David;Zepeda-Velazquez, Carlos;Bolshan, Yuri;Poda, Gennady;Wu, Hong;Dong, Aiping;Kuznetsova, Ekaterina;Marcellus, Richard;Senisterra, Guillermo;Dombrovski, Ludmila;Hajian, Taraneh;Kiyota, Taira;Schapira, Matthieu;Arrowsmith, Cheryl H.;Brown, Peter J.;Vedadi, Masoud;Al-awar, Rima. And the article was included in Journal of Medicinal Chemistry in 2016.Recommanded Product: Benzo[b]thiophen-3-ylboronic acid This article mentions the following:

WD repeat-containing protein 5 (WDR5) is an important component of the multiprotein complex essential for activating mixed-lineage leukemia 1 (MLL1). Rearrangement of the MLL1 gene is associated with onset and progression of acute myeloid and lymphoblastic leukemias, and targeting the WDR5-MLL1 interaction may result in new cancer therapeutics. Our previous work showed that binding of small mol. ligands to WDR5 can modulate its interaction with MLL1, suppressing MLL1 methyltransferase activity. Initial structure-activity relationship studies identified N-(2-(4-methylpiperazin-1-yl)-5-substituted-phenyl) benzamides as potent and selective antagonists of this protein-protein interaction. Guided by crystal structure data and supported by in silico library design, we optimized the scaffold by varying the C-1 benzamide and C-5 substituents. This allowed us to develop the first highly potent (K_disp < 100 nM) small mol. antagonists of the WDR5-MLL1 interaction and demonstrate that N-(4-(4-methylpiperazin-1-yl)-3′-(morpholinomethyl)-[1,1′-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide 16d (OICR-9429) is a potent and selective chem. probe suitable to help dissect the biol. role of WDR5. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6Recommanded Product: Benzo[b]thiophen-3-ylboronic acid).

Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Recommanded Product: Benzo[b]thiophen-3-ylboronic acid

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Thiophene/thiazole-benzene replacement on guanidine derivatives targeting α₂-Adrenoceptors was written by Flood, Aoife;Trujillo, Cristina;Sanchez-Sanz, Goar;Kelly, Brendan;Muguruza, Carolina;Callado, Luis F.;Rozas, Isabel. And the article was included in European Journal of Medicinal Chemistry in 2017.Reference of 5936-58-3 This article mentions the following:

Searching for improved antagonists of α₂-adrenoceptors, a thorough theor. study comparing the aromaticity of phenyl-, pyridinyl-, thiophenyl- and thiazolylguanidinium derivatives were carried out [at M06-2X/6-311++G(p,d) computational level] confirming that thiophene and thiazole were good ‘ring equivalent’ to benzene in these guanidinium systems. Based on these results, a small but chem. diverse library of guanidine derivatives were synthesized to explore the effect that the bioisosteric change has on affinity and activity at α₂-adrenoceptors in comparison with our previously studied Ph derivatives All compounds were tested for their α₂-adrenoceptor affinity and unsubstituted guanidinothiophenes displayed the strongest affinities in the same range as the Ph analogs. In the case of cycloalkyl systems, thiophenes with 6-membered rings showed the largest affinities, while for the thiazoles the 5-membered analog presented the strongest affinity. From all the compounds tested for noradrenergic activity, only one compound exhibited agonistic activity, while two compounds showed very promising antagonism of α₂-adrenoceptors. In the experiment, the researchers used many compounds, for example, 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (cas: 5936-58-3Reference of 5936-58-3).

2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (cas: 5936-58-3) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Reference of 5936-58-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Efficient one pot multi-component domino Aldol condensation-Michael addition-Suzuki coupling reaction for the highly functionalized quinolines was written by Ubba, Eethamukkala;Kumar, Y. Suneel;Dasaradhan, C.;Khan, Fazlur-Rahman Nawaz;Jeong, Euh Duck;Chung, Eun Hyuk. And the article was included in Tetrahedron Letters in 2015.Formula: C8H7BO2S This article mentions the following:

A parallel and advantageous multi-component one pot reaction has been developed utilizing domino Aldol condensation-Michael addition-Suzuki coupling approach for a variety of 2,3-disubstituted highly functionalized quinolines. The domino reactions of 2-chloro-3-formylquinolines, acetophenones, and distinctive boronic acids, were carried out utilizing PdCl₂(PPh₃)₂/tripotassium phosphate/ethanol-water system. At 80 °C they gave diversified functionalized quinolines in good yields. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6Formula: C8H7BO2S).

Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Formula: C8H7BO2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Enantioselective aza-Michael reaction of hydrazide to chalcones through the nonactivated amine moiety conjugated addition was written by Jiang, Jun;Cai, Yunfei;Chen, Weiliang;Lin, Lili;Liu, Xiaohua;Feng, Xiaoming. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2011.Application of 3988-77-0 This article mentions the following:

The catalytic asym. aza-Michael reaction of benzoyl hydrazine toward chalcones through the nonactivated amine moiety conjugated addition was facilitated by the developed N,N’-dioxide-Sc(OTf)₃ complex under mild conditions, affording the pharmacol. and synthetically useful products in moderate to high yields with up to 97% ee. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Application of 3988-77-0).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Application of 3988-77-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem