Day: February 27, 2023

Iron-Catalyzed Alkylzincation of Terminal Alkynes was written by Huang, Qiang;Wang, Wei-Na;Zhu, Shou-Fei. And the article was included in ACS Catalysis in 2022.SDS of cas: 4298-52-6 This article mentions the following:

Although carbozincation of terminal alkynes is a promising method for the synthesis of alkenylzinc reagents, many challenges, especially the chemo-, regio-, and stereoselectivity, remain to be addressed. The authors herein report an operationally simple, mild method for Fe-catalyzed alkylzincation of terminal alkynes to produce a diverse array of alkenylzinc compounds in high yields with high anti-Markovnikov selectivity and high cis stereoselectivity. Using this method, the authors realized a cis alkylzincation of terminal alkynes, and the method has a wide substrate scope (being suitable for aryl, alkenyl, alkyl, and heteroatom-substituted acetylenes) and good functional group tolerance. Because the C(sp²)-Zn bonds of the products can be readily transformed, the method provides a competitive alternative to traditional methods for the selective synthesis of trisubstituted olefins. The Fe catalyst developed in this study exhibited irreplaceable reactivity in alkyne alkylzincation. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6SDS of cas: 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.SDS of cas: 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Homolytic N-S Bond Cleavage in Vinyl Triflimides Enabled by Triplet-Triplet Energy Transfer was written by Strauch, Christina;Schroeder, Sebastian;Grelier, Gwendal;Niggemann, Meike. And the article was included in Chemistry – A European Journal in 2022.HPLC of Formula: 4298-52-6 This article mentions the following:

Vinyl triflimides are a new compound class with unknown reactivity. A computational anal. identified homolytic cleavage of the N-Tf bond induced by triplet-triplet energy transfer (EnT) as a highly interesting reaction type that might be accessible. A combination of exptl. and mechanistic work verified this hypothesis and proved the generated radicals to be amenable to radical-radical coupling. Thereby, vinyl triflimides H₂C:C(Ar)NTf₂ (Ar = Ph, 4-BrC₆H₄, 2-thienyl, etc.) were transformed into a range of α-quaternary, β-trifluoromethylated amines ArC(R)(NHTf)CH₂CF₃ (R = Me, Et, CN, Ph, etc.) in a 1,2-difunctionalization reaction with no need for external CF₃ reagents. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6HPLC of Formula: 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.HPLC of Formula: 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A convenient transformation of alkynes to α-hydroxy-α-CF₃-γ-ketoester derivatives via H₃PO₄-catalyzed tandem hydration and aldol condensation was written by Wang, Jiali;Yao, Jun;Jia, Chunqi;Hu, Dandan;Chen, Yun-Hua;Song, Jinyu;Zhang, Jun-Qi;Ren, Hongjun. And the article was included in Green Chemistry in 2022.Safety of 2-Ethynylthiophene This article mentions the following:

A robust metal-free catalytic strategy for the rapid construction of the valuable α-hydroxy-α-CF₃-γ-ketoester skeleton with cheap and easily available stock chems. (alkynes and trifluoropyruvate) as the starting material was described. This protocol showed very good functional group tolerance and was easily scaled up. Importantly, compared with transition metal-catalyzed methods, this strategy was made more environmentally friendly by employing a catalytic amount of H₃PO₄ as the catalyst. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Safety of 2-Ethynylthiophene).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Safety of 2-Ethynylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A Study on FCC gasoline hydro-upgrading was written by Yang, Xiaoyu;Yuan, Jingli;Wang, Xiangsheng;Guo, Xinwen. And the article was included in Zhongwai Nengyuan in 2012.Application of 1795-01-3 This article mentions the following:

Producing clean gasoline with low sulfur and olefin contents and high octane number is required by the need for achieving sustainable growth of energy economy. China began implementing the Limits and Measurement of Pollutants Emitted by Light Vehicles (China Phase IV) in 2011 nationwide. According to the standard, the volume fraction of olefin in gasoline should not exceed 18%, that of aromatic hydrocarbon not exceed 35%, and the content of sulfur not exceed 50μg/g. Around 80% of gasoline products in China come from FCC gasoline and the sulfur content of FCC gasoline accounts for some 90% of sulfur in gasoline. FCC gasoline contains high contents of olefin (mass fraction : 30%-55%) and sulfur (150-1500μg/g). Sulfur in FCC gasoline primarily exists in the forms of thiophene and thiophene derivatives The article analyzes the contribution of hydrocarbon composition in FCC gasoline fractions to octane value and distribution of sulfide and conducts a preliminary forecast of the possibility and results of reactions such as hydrogen transfer, isomerization and aromatic hydrocarbon generation from a thermodn. perspective. The article suggests retaining more high octane-value olefin components while ensuring deep desulfurization and highly selectively converting olefin to aromatic hydrocarbon to maintain the octane value of gasoline products produced. In the experiment, the researchers used many compounds, for example, 3-Ethylthiophene (cas: 1795-01-3Application of 1795-01-3).

3-Ethylthiophene (cas: 1795-01-3) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Application of 1795-01-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Electrically Controlled Lasing in Supercooled Liquid Crystal Blue Phase I Microdroplets was written by Petriashvili, Gia;Hamdi, Ridha;Chanishvili, Andro;Zurabishvili, Tsisana;Chubinidze, Ketevan;Ponjavidze, Nino. And the article was included in ACS Applied Electronic Materials in 2020.Reference of 7128-64-5 This article mentions the following:

We have prepared the liquid crystal blue phase (BP) microdroplets emulsified in the glycerol environment and investigated their electro-optical properties upon the applied elec. field. We showed that the lasing from the supercooled luminescent dye-doped BPI microdroplets can be controlled elec. When the elec. field intensity is increased, the lasing intensity is increased too along with the linewidth that decreases from 6 to 2.5 nm. Besides, the laser lines were shifted toward the shorter wavelength by 11 nm. All effects were achieved via elec. field-stimulated structural and sym. modification of BPI microdroplets, resulting in their optical anisotropy and birefringence. Luminescent dye-doped liquid crystal blue phase-based microdroplets can find applications as elec. controlled microlaser sources for microphotonics and environmental sensing. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5Reference of 7128-64-5).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Reference of 7128-64-5

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Preparation and characterization of 4-bromobenzo[b]thiophene was written by Feng, Bai-cheng;Li, Wei-ping;Du, Zeng. And the article was included in Qingdao Keji Daxue Xuebao, Ziran Kexueban in 2013.HPLC of Formula: 5118-13-8 This article mentions the following:

4-Bromobenzo[b]thiophene was synthesized using 3-bromothiophenol and 2-bromo-1,1-dimethoxyethane as starting materials by SN2 nucleophilic substitution and intramol. cyclization. The optimum conditions were obtained by examining the effects of solvent, temperature, reaction time and PPA dosage on product yield. The obtained optimum conditions of the first step were DMF as solvent and reaction temperature 35-45°C; and the second step were 100 mL of chlorobenzene as solvent, PPA 20 g and reaction temperature 110°C. The results showed that the reaction conditions were moderate and the yield of product was 64.2% with simple workup. The structure of product was characterized by IR, GC-MS and ¹H NMR. In the experiment, the researchers used many compounds, for example, 4-Bromobenzo[b]thiophene (cas: 5118-13-8HPLC of Formula: 5118-13-8).

4-Bromobenzo[b]thiophene (cas: 5118-13-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.HPLC of Formula: 5118-13-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Optimization of the metabolic stability of a fluorinated cannabinoid receptor subtype 2 (CB₂) ligand designed for PET studies was written by Heimann, Dominik;Boergel, Frederik;de Vries, Henk;Patberg, Marius;Jan-Smith, Eliot;Frehland, Bastian;Schepmann, Dirk;Heitman, Laura H.;Wuensch, Bernhard. And the article was included in European Journal of Medicinal Chemistry in 2018.Computed Properties of C2H4O4S This article mentions the following:

The central CB₂ receptor represents a promising target for the treatment of neuroinflammatory diseases as CB₂ activation mediates anti-inflammatory effects. Recently, the F-18 labeled PET radiotracer [¹⁸F]7a was reported, which shows high CB₂ affinity and high selectivity over the CB₁ subtype but low metabolic stability due to hydrolysis of the amide group. Based on these findings twelve bioisosteres of 7a were synthesized containing a non-hydrolysable functional group instead of the amide group. The secondary amine 23a (K_i=7.9nM) and the ketone 26a (K_i=8.6nM) displayed high CB₂ affinity and CB₂:CB₁ selectivity in in vitro radioligand binding studies. Incubation of 7a, 23a and 26a with mouse liver microsomes and LC-quadrupole-MS anal. revealed a slightly higher metabolic stability of secondary amine 23a, but a remarkably higher stability of ketone 26a in comparison to amide 7a. Furthermore, a logD_7.4 value of 5.56±0.08 was determined for ketone 26a by micro shake-flask method and LC-MS quantification. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Computed Properties of C2H4O4S).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Computed Properties of C2H4O4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Rational design of reversibly photochromic molecules with aggregation-induced emission by introducing photoactive thienyl and benzothienyl groups was written by Zhou, Shasha;Guo, Sidan;Liu, Weidong;Yang, Qiaoying;Sun, Huili;Ding, Riqing;Qian, Zhaosheng;Feng, Hui. And the article was included in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2020.Related Products of 113893-08-6 This article mentions the following:

Herein, we proposed a general strategy to design reversible photochromic mols. with solid-state fluorescence by introducing photoactive thienyl and benzothienyl groups into an AIE-active mol. skeleton. The combination of a thienyl or benzothienyl group and a triphenylethene in the right manner enabled the mols. to possess unique aggregation-induced emission properties and reversible photo-controlled changes in color and fluorescence in solid state. Theor. anal. revealed that photo-triggered cyclization and cycloreversion reactions were responsible for the reversible photochromism and photoinduced fluorescence switching, and the enlargement of the conjugation of the introduced photoactive units can significantly promote the cyclization reactions and the photochromic processes. The excellent performance of these photochromic mols. with aggregation-induced emission activity in a photoswitchable patterning paper and multiple encryption of anti-counterfeiting of a banknote demonstrated that they are perfectly suited for surface-involved photo-controlled applications such as information storage and data encryption. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6Related Products of 113893-08-6).

Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Related Products of 113893-08-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Study of new luminophores for use in modern scintillation cocktails was written by Janda, Jiri;Rajchl, Erik. And the article was included in Journal of Luminescence in 2018.Synthetic Route of C26H26N2O2S This article mentions the following:

This paper deals with the study of 1-phenyl-3-(2,4,6-trimethyl-phenyl)-2-pyrazoline, 2,2′,7,7′-tetrakis(N,N-diphenyl-amino)-9,9′-spirobifluorene, 2-(4-biphenylyl)-6-phenylbenzoxazole and 9,9′-bifluorenyl as possible replacements of the existing and most widely used luminophore (2.5-diphenyloxazole (PPO)) in contemporary scintillators. The study is focused on the determination of emission wavelength, concentration optimization, the influence of the wavelength shifters POPOP and bis-MSB. In addition, the response to alpha and beta radiation were measured, in particular, the pulse length index (PLI) was determined Finally, yet importantly, the effect of emulsifiers on the shape of the spectrum and the solubility of the aqueous phase was tested. The results obtained were compared with the com. available Aqualight scintillation cocktail. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5Synthetic Route of C26H26N2O2S).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Synthetic Route of C26H26N2O2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Electrochemical Dearomatizing Spirocyclization of Alkynes with Dimethyl 2-Benzylmalonates to Spiro[4.5]deca-trienones was written by Li, Laiqiang;Hou, Zhong-Wei;Li, Pinhua;Wang, Lei. And the article was included in Journal of Organic Chemistry in 2022.HPLC of Formula: 4298-52-6 This article mentions the following:

An electrochem. dearomatizing spirocyclization of alkynes with di-Me 2-benzylmalonates for the preparation of spiro[4.5]deca-trienones had been developed. This approach adopted ferrocene (Cp₂Fe) as an electrocatalyst to produce carbon-centered radical intermediates from C-H-based malonates, which obviated the forthputting of noble-metal reagents, sacrificial chem. oxidants and 2-bromomalonates. A wide variety of spiro compounds were efficiently prepared with satisfactory results under mild conditions. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6HPLC of Formula: 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.HPLC of Formula: 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem