Rh-Catalyzed Highly Enantioselective Synthesis of Aliphatic Sulfonyl Fluorides was written by Moku, Balakrishna;Fang, Wan-Yin;Leng, Jing;Li, Linxian;Zha, Gao-Feng;Rakesh, K. P.;Qin, Hua-Li. And the article was included in iScience in 2019.Reference of 113893-08-6 This article mentions the following:
Rh-catalyzed, highly enantioselective (up to 99.8% ee) synthesis of aliphatic sulfonyl fluorides (R)/(S)-RCH(R1)CH2SO2F (R = Ph, dibenzo[b,d]thiophen-4-yl, thiophen-3-yl, etc.; R1 = naphthalen-1-yl, dibenzo[b,d]furan-4-yl, benzo[b]thiophen-3-yl, etc.) was accomplished. This protocol provides a portal to a class of novel 2-aryl substituted chiral sulfonyl fluorides, which are otherwise extremely difficult to access. This asym. synthesis has the feature of mild conditions, excellent functional group compatibility, and wide substrate scope (51 examples) generating a wide array of structurally unique chiral β-arylated sulfonyl fluoride (R)-2-(dibenzo[b,d]thiophen-4-yl)-2-phenylethanesulfonyl fluoride for sulfur(VI) fluoride exchange (SuFEx) click reaction and drug discovery. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6Reference of 113893-08-6).
Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Reference of 113893-08-6
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem