Synthesis of Pyridine-SF4-Isoxazolines Using the Functionality of trans-Tetrafluoro-λ6-sulfanyl Rodlike Linkers was written by Maruno, Koki;Hada, Kenshiro;Sumii, Yuji;Nagata, Osamu;Shibata, Norio. And the article was included in Organic Letters in 2022.Synthetic Route of C6H4S This article mentions the following:
The tetrafluoro-λ6-sulfanyl (SF4) moiety has been relatively undeveloped since its discovery in the 1970s. In this study, we synthesized pyridine-SF4-isoxazolines, in which the two heterocycles are connected by a rodlike trans-SF4 linker, via the regioselective 1,3-dipolar cycloaddition of pyridine-SF4-alkynes and nitrones in the presence of triethylamine. SF4 linkers are a viable alternative to para-substituted benzenes, alkynes, and bicyclo[1.1.1]pentyl derivatives in drug design, and pyridine-SF4-isoxazolines have potential applications in drug development. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0Synthetic Route of C6H4S).
3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Synthetic Route of C6H4S
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem