Synthesis of Novel Chiral Phosphoric Acid-Bearing Two Acidic Phenolic Hydroxyl Groups and its Catalytic Evaluation for Enantioselective Friedel-Crafts Alkylation of Indoles and Enones was written by Liu, Xiong-Li;Yu, Zhang-Biao;Pan, Bo-Wen;Chen, Lin;Feng, Ting-Ting;Zhou, Ying. And the article was included in Journal of Heterocyclic Chemistry in 2015.Category: benzothiophene This article mentions the following:
A novel chiral phosphoric acid catalyst bearing two acidic phenolic hydroxyl groups was synthesized. Its catalytic activity as a chiral Bronsted acid has been examined in the enantioselective Friedel-Crafts alkylation of indoles and enones as a model reaction. In comparison with the other chiral phosphoric acid catalysts, the reaction catalyzed by the novel chiral catalyst afforded the desired 3-substituted indoles I (R1 = H, OCH3, Br; R2 = H, CH; R3 = Ph, n-Pr, 2-naphthyl, 2-thienyl, 2-furyl; R4 = Ph, CH3, 2-thienyl, 4-ClC6H4, 4-CH3OC6H4) in a higher enantioselectivity (up to 69% ee). In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Category: benzothiophene).
3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Category: benzothiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem