Enantioselective aza-Michael reaction of hydrazide to chalcones through the nonactivated amine moiety conjugated addition was written by Jiang, Jun;Cai, Yunfei;Chen, Weiliang;Lin, Lili;Liu, Xiaohua;Feng, Xiaoming. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2011.Application of 3988-77-0 This article mentions the following:
The catalytic asym. aza-Michael reaction of benzoyl hydrazine toward chalcones through the nonactivated amine moiety conjugated addition was facilitated by the developed N,N’-dioxide-Sc(OTf)3 complex under mild conditions, affording the pharmacol. and synthetically useful products in moderate to high yields with up to 97% ee. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Application of 3988-77-0).
3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Application of 3988-77-0
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem