Substituted 1-methyl-4-phenylpyrrolidin-2-ones – Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors was written by Hilton-Proctor, J. P.;Ilyichova, O.;Zheng, Z.;Jennings, I. G.;Johnstone, R. W.;Shortt, J.;Mountford, S. J.;Scanlon, M. J.;Thompson, P. E.. And the article was included in European Journal of Medicinal Chemistry in 2020.Application In Synthesis of Benzo[b]thiophen-3-ylboronic acid This article mentions the following:
The synthesis of a 4-Ph substituted analog – 1-methyl-4-phenylpyrrolidin-2-one – and the use of aryl substitution reactions as a divergent route for derivatives I (R = H, Br, Ph, 2-phenylethyl, etc.; R1 = 2-Br, 4-Ph, morpholine-4-sulfonyl, etc.) were described. Ultimately, this has led to structurally complex, chiral compounds (R/S)-II (R2 = H, Me; R3 = H, 3,4-dimethoxyphenyl; R4 = H, N,N-diethylsulfamoyl) with progressively improved affinity as inhibitors of bromodomain-containing protein 4. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6Application In Synthesis of Benzo[b]thiophen-3-ylboronic acid).
Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is also used in the manufacturing of dyes such as thioindigo.Application In Synthesis of Benzo[b]thiophen-3-ylboronic acid
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem