Combinatorial synthesis of new fluorescent scaffolds using click chemistry was written by Cleemann, Felix;Kum-Cheung, Wendy Loa;Karuso, Peter. And the article was included in Tetrahedron Letters in 2022.COA of Formula: C6H4S This article mentions the following:
Azides and acetylenes are bio-orthogonal functional groups that can be readily coupled using copper(I)- or ruthenium(II)- catalyzed 1,3-dipolar cycloaddition reactions. Using non-fluorescent aromatic azides and aromatic acetylenes, covering a range of electron rich and poor building blocks, the Huisgen cycloaddition afford 1,4-disubstituted or 1,5-disubstituted 1,2,3-triazoles. Using a combinatorial approach by running reaction in parallel in polypropylene 96-well plates we discovered several new fluorescent 1,2,3-triazoles scaffolds. These compounds show diverse interactions with biomols. that could find applications in biol. in, for example, fluorescence microscopy or biomol. quantification. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0COA of Formula: C6H4S).
3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.COA of Formula: C6H4S
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem