Synthesis of thieno[2,3-d]oxazines and thieno[2,3-d]thiazines as subtype specific kainate receptor antagonists was written by Briel, D.;Rybak, A.;Mann, S.;Kronbach, C.;Unverferth, K.. And the article was included in Current Medicinal Chemistry in 2009.Computed Properties of C9H11NO2S This article mentions the following:
For the development of new antiepileptics the kainate receptors, GluR6 and GluR5, are important targets. Based on the anticonvulsant effects of chinazolines and thieno[2,3-d]pyrimidines that are known from the literature, thieno[2,3-d][1.3]oxazines were synthesized and studied for their inhibitory properties at GluR6 and GluR5 receptors. The strongest inhibitor activity was observed with 5-methyl-6-phenyl-thieno[2,3-d][1.3]oxazines with Cl or C3-substituents in position 2. The 2-trihalide-methyl-substituted compounds were the most active inhibitors at the GluR5-receptor (IC50 = 23.4 μmol, 16 μl). The 2-isopropyl-substituted compound displayed the strongest activity at the GluR6-receptor (IC50 = 8.7 μmol). A number of thieno[2,3-d][1.3]thiazines and thieno[2,3-d]pyrimidines that were synthesized from the thieno[2,3][1.3]oxazines did not show any activity. In the experiment, the researchers used many compounds, for example, 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (cas: 5936-58-3Computed Properties of C9H11NO2S).
2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (cas: 5936-58-3) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is also used in the manufacturing of dyes such as thioindigo.Computed Properties of C9H11NO2S
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem