Catalytic promiscuity enabled by photoredox catalysis in nicotinamide-dependent oxidoreductases was written by Biegasiewicz, Kyle F.;Cooper, Simon J.;Emmanuel, Megan A.;Miller, David C.;Hyster, Todd K.. And the article was included in Nature Chemistry in 2018.SDS of cas: 1072-53-3 This article mentions the following:
Strategies that provide enzymes with the ability to catalyze non-natural reactions are of considerable synthetic value. Photoredox catalysis has proved adept at expanding the synthetic repertoire of existing catalytic platforms, yet, in the realm of biocatalysis it has primarily been used for cofactor regeneration. Here we show that photoredox catalysts can be used to enable new catalytic function in nicotinamide-dependent enzymes. Under visible-light irradiation, xanthene-based photocatalysts enable a double-bond reductase (DBR) to catalyze an enantioselective deacetoxylation. Mechanistic experiments support the intermediacy of an α-acyl radical, formed after the elimination of acetate. Isotopic labeling experiments support nicotinamide as the source of the hydrogen atom. Preliminary calculations and mechanistic experiments suggest that binding to the protein attenuates the reduction potential of the starting material, an important feature for localizing radical formation to the enzyme active site. The generality of this approach is highlighted with the radical dehalogenation of α-bromoamides catalyzed by ketoreductases (KREDs) with Eosin Y as a photocatalyst. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3SDS of cas: 1072-53-3).
1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.SDS of cas: 1072-53-3
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem