Preheated fly-ash catalyzed aldol condensation: efficient synthesis of chalcones and antimicrobial activities of some 3-thienyl chalcones was written by Arulkumaran, Ranganathan;Vijayakumar, Sambandhamoorthy;Sakthinathan, S. Pazhanivel;Kamalakkannan, Dakshnamoorthy;Ranganathan, Kaliyaperumal;Suresh, Ramamoorthy;Sundararajan, Rajasekaran;Vanangamudi, Ganesan;Thirunarayanan, Ganesamoorthy. And the article was included in Journal of the Chilean Chemical Society in 2013.Formula: C13H10OS This article mentions the following:
In the present study the authors have prepared a series of chalcone derivatives by a solvent-free aldol condensation mediated by microwave irradiation The synthesis of the target compounds was achieved using heat-treated fly ash (ash residue) as a catalyst. The yields of the ketones are more than 60%. The synthesized chalcones were characterized by their anal., phys. and spectral data. The antimicrobial activities of substituted styryl 3-thienyl ketones were studied using the Bauer-Kirby method. The title compounds thus formed included 3-(4-nitrophenyl)-1-(3-thienyl)-2-propen-1-one (I) and related substances, such as 2-thiophene derivatives, naphthalene derivatives, benzenamine derivatives, halobenzene derivatives, phenol derivatives, etc. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Formula: C13H10OS).
3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Formula: C13H10OS
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem