Radical Hydro-Fluorosulfonylation of Unactivated Alkenes and Alkynes was written by Wang, Peng;Zhang, Honghai;Zhao, Mingqi;Ji, Shuangshuang;Lin, Lu;Yang, Na;Nie, Xingliang;Song, Jinshuai;Liao, Saihu. And the article was included in Angewandte Chemie, International Edition in 2022.Safety of 3-Ethynylthiophene This article mentions the following:
Here, reported the first establishment of radical hydro-fluorosulfonylation of alkenes, which was enabled by using 1-fluorosulfonyl 2-aryl benzoimidazolium (FABI) as an effective redox-active radical precursor. This method provided a new and facile approach for the synthesis of aliphatic sulfonyl fluorides from unactivated alkenes, and could be further applied to the late-stage modifications of natural products and peptides, as well as ligation of drugs in combination with click chem. Remarkably, this system could enable the radical hydro-fluorosulfonylation of alkynes, afforded valuable alkenylsulfonyl fluoride products with a rare, high Z-selectivity, which were normally less stable and more challenging to synthesize in comparison with the E-configured products. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0Safety of 3-Ethynylthiophene).
3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is also used in the manufacturing of dyes such as thioindigo.Safety of 3-Ethynylthiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem