Direct Carboxylation of Electron-Rich Heteroarenes Promoted by LiO-tBu with CsF and [18]Crown-6 was written by Shigeno, Masanori;Hanasaka, Kazuya;Sasaki, Keita;Nozawa-Kumada, Kanako;Kondo, Yoshinori. And the article was included in Chemistry – A European Journal in 2019.Computed Properties of C11H10O3S This article mentions the following:
The combination of LiO-tBu, CsF, and [18]crown-6 efficiently promoting the direct C-H carboxylation of electron-rich heteroarenes (benzothiophene, thiophene, benzofuran, and furan derivatives) I (R = Me, CN, Br, MeO, Cl, F; R1 = H, CH3, Br) and II (R2 = Br, C6H5, C(O)C6H5, etc.; R3 = H; R2R3 = CH=CH-CH=CH; X = O, S) has been demonstrated. A variety of functional groups, including Me, methoxy, halo, cyano, amide, and keto moieties, is compatible with this system. The reaction proceeds via the formation of a tert-Bu carbonate species. In the experiment, the researchers used many compounds, for example, Methyl 5-methoxybenzo[b]thiophene-2-carboxylate (cas: 19492-99-0Computed Properties of C11H10O3S).
Methyl 5-methoxybenzo[b]thiophene-2-carboxylate (cas: 19492-99-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Computed Properties of C11H10O3S
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem