Lanthanide amide-catalyzed one-pot functionalization of isatins: synthesis of spiro[cyclopropan-1,3′-oxindoles] and 2-oxoindolin-3-yl phosphates was written by Peng, Cheng;Zhai, Jiaojiao;Xue, Mingqiang;Xu, Fan. And the article was included in Organic & Biomolecular Chemistry in 2017.Related Products of 3988-77-0 This article mentions the following:
Lanthanide amide-catalyzed one-pot reaction of isatins I (R1 = H, 7-F, 5-CH3, etc.; R2 = C2H5, CH2CH=CH2, CH2C6H5), di-Et phosphite and activated alkenes R3CH=C(R4)R5 [R3 = H, C6H5, C(O)2C2H5, etc.; R4 = H, CH3, C(O)C6H5, etc.; R5 = C(O)2CH3, P(O)(OCH3)2] was developed and a series of spiro[cyclopropan-1,3′-oxindoles] II was obtained in moderate to excellent yields. The reaction is stereoselective and the two substituents at the 2 and 3-positions of the cyclopropane in the major product are in the trans configuration. A four-step mechanism involving the Pudovik reaction, Brook rearrangement, Michael addition, and intramol. nucleophilic substitution is proposed, and an umpolung strategy was used in the process. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Related Products of 3988-77-0).
3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Related Products of 3988-77-0
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem