Thiophene bioisosteres. Synthesis of 2-methyl-4-oxothieno [2,3-d] pyrimidines was written by Noverola, Salvador Vega. And the article was included in Anales de la Real Academia de Farmacia in 1976.Computed Properties of C9H11NO2S This article mentions the following:
Thienopyrimidinones I [RR1 = (CH2)4, R = Me, R1 = H; R2 = (CH2)3OCHMe2, NHCO2Et, NHCOCH2Ph, NHBz, (CH2)nNR3R4, n = 2, 3, NR3R4 = NMe2, NEt2, morpholino, pyrrolidino] were prepared by treating cyclohexanone and S or HSCH2COMe with NCCH2CO2Et, acetylating II (R5 = H, R6 = Et), hydrolyzing, cyclizing II (R5 = Ac, R6 = H) with Ac2O, and treating the oxazines III with R2NH2 with prolonged heating. Intermediates IV of the reaction of III with R2NH2 were isolated at shorter reaction times. In the experiment, the researchers used many compounds, for example, 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (cas: 5936-58-3Computed Properties of C9H11NO2S).
2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (cas: 5936-58-3) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Computed Properties of C9H11NO2S
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem