Palladium-Catalyzed Carbonylative Sonogashira/Annulation Reaction: Synthesis of Indolo[1,2-b]isoquinolines was written by Li, Lin;Liu, Xin-Lian;Qi, Zhuang;Yang, Ai-Hua;Ma, Ai-Jun;Peng, Jin-Bao. And the article was included in Organic Letters in 2022.Category: benzothiophene This article mentions the following:
A palladium-catalyzed carbonylative Sonogashira/annulation reaction for the synthesis of indolo[1,2-b]isoquinolines I [Ar = Ph, 4-MeC6H4, 3,4-di-MeOC6H3, etc.; R1 = H, 3-F, 2-F, 2-Cl, 3-Cl, 3-Me; R2 = H, 8-F, 9-Me ] was developed. Tetracyclic 6/5/6/6 indoline skeletons I were synthesized in moderate to good yields from easily available 2-bromo-N-(2-iodophenyl)benzamides and terminal alkynes. Notably, this efficient methodol. established three C-C bonds and a C-N bond through a one-step transformation and provided a new method for the synthesis of indolo[1,2-b]isoquinoline derivatives I. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0Category: benzothiophene).
3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Category: benzothiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem