Palladium-Catalyzed Tail-to-Tail Reductive Dimerization of Terminal Alkynes to 2,3-Dibranched Butadienes was written by Guo, Hongyu;Zhang, Sheng;Li, Yang;Yu, Xiaoqiang;Feng, Xiujuan;Yamamoto, Yoshinori;Bao, Ming. And the article was included in Angewandte Chemie, International Edition in 2022.Recommanded Product: 2-Ethynylthiophene This article mentions the following:
The palladium-catalyzed tail-to-tail reductive dimerization of terminal alkynes was described for the first time. Aromatic terminal alkynes bearing diverse and sensitive functional groups as well as aliphatic terminal alkynes are efficiently transformed to 2,3-dibranched butadienes H2C(R)CC(R)CH2 [R = Ph, 2-naphthyl, 2-thienyl, etc.]. The key to achieve a selective tail-to-tail reductive dimerization reaction is to control appropriately the acidity of the reaction solution, which is accomplished by a combined use of pivalic acid and para-toluenesulfonic acid. The tail-to-tail reductive dimerization reaction is proposed to proceed via a cationic alkenyl palladium intermediate under acidic conditions. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Recommanded Product: 2-Ethynylthiophene).
2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Recommanded Product: 2-Ethynylthiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem