Determination of five fluorescent whitening agents in foam plastic tableware by high performance liquid chromatography tandem mass spectrometry was written by Du, Zhi-feng;Xian, Yan-ping;Liu, Fu-jian;Huang, Jin-feng;Wu, Yu-luan;Guo, Xin-dong;Wang, Yong-hua;Luo, Dong-hui. And the article was included in Xiandai Shipin Keji in 2013.Safety of 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene This article mentions the following:
A simple and sensitive method has been developed for the simultaneous determination of five fluorescent whitening agents (FWA135, FWA184, FWA367, FWA368 and FWA393) in foam plastic tableware using high performance liquid chromatog. tandem mass spectrometry (HPLC-MS/MS). The samples were extracted with trichloromethane, and the polymer in the extracts were precipitated by adding methanol. The separation of five FWAs was carried out on a Phenomenex kinetex C18 column (2.1 mm × 100 mm, 2.6 μm) by gradient elution with 0.1% formic acid methanol and 0.1% formic acid as mobile phase. Electrospray ionization mass was operated in the pos. mode (ESI+) using multiple reaction monitoring (MRM) for the qual. and quant. anal. of five FWAby retention time and ion ratio. The result indicated that the linear correlation coefficients (r > 0.995) of five FWAs were obtained with the linear relationship between 0.5 to 50 μg/L. The limits of detection (ILOD, S/N = 3) were ranged from 0.1 μg/L to 0.5 μg/L, and the limits of qualification of the method (MLOQ, S/N = 10) were varied from 0.4 μg/kg to 2.0 μg/kg. The recoveries of five FWAs from spiked samples at the spiking levels of 2 μg/kg, 8 μg/kg and 200 μg/kg were between 86.4% and 98.4% with RSD (n = 6) less than 3.9% to 8.1%. The method was simple and precise for the determination of five FWAs in foam plastic tableware. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5Safety of 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene).
2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Safety of 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem