Synthesis of Pyrrolo[2,1-a]isoquinolines through Cu-Catalyzed Condensation/Addition/Oxidation/Cyclization Cascade was written by Cui, Hai-Lei;Chen, Xiao-Hui. And the article was included in Journal of Organic Chemistry in 2022.COA of Formula: C6H4S This article mentions the following:
A copper-catalyzed synthesis of pyrrolo[2,1-a]isoquinolines I [R1 = H, 6-Br, 8-OMe, etc.; R2 = Ph, 4-O2NC6H4, 4-ClC6H4, etc.; R3 = Ph, 4-EtC6H4, 4-FC6H4, etc.] via Cu-catalyzed cascade condensation/addition/oxidation/cyclization of terminal alkynes, aldehydes and tetrahydroisoquinolines. A variety of pyrrolo[2,1-a]isoquinolines I were prepared in 17-69% yield. Modifications through simple chem. transformations provided highly functionalized mols. containing a privileged framework. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6COA of Formula: C6H4S).
2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.COA of Formula: C6H4S
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem