Proteolytic susceptibility of hemoglobin synthesized in the presence of amino acid analogs was written by Ayukawa, Saburo;Fisher, Joyce M.;Rabinovitz, Marco. And the article was included in Molecular Pharmacology in 1981.Formula: C7H9NO3S This article mentions the following:
α-Amino acid analogs with a hetero atom on the β-C, when incorporated into protein by a reticulocyte lysate, render the newly formed protein particularly sensitive to proteolytic hydrolysis. In the experiment, the researchers used many compounds, for example, 2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid (cas: 32595-59-8Formula: C7H9NO3S).
2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid (cas: 32595-59-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Formula: C7H9NO3S
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem