Day: February 22, 2023

Copper-mediated Chan-Evans-Lam N-arylation of 5-methylene-4-aryl-1,5-dihydro-2H-pyrrol-2-one derivatives was written by Almohaywi, Basmah;Iskander, George;Yu, Tsz Tin;Bhadbhade, Mohan;Black, David StC.;Kumar, Naresh. And the article was included in Tetrahedron Letters in 2018.Recommanded Product: 113893-08-6 This article mentions the following:

A simple and efficient procedure for the synthesis of N-aryl 5-methylene-4-aryl-1,5-dihydro-2H-pyrrol-2-one derivatives, e.g., I. has been developed through copper-mediated C-N bond formation. The synthetic protocol allows for versatile and robust C-N arylation with a range of readily available boronic acids under mild conditions. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6Recommanded Product: 113893-08-6).

Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Recommanded Product: 113893-08-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Organic elemental analysis: A new universal approach to authenticity/quality control of pharmaceuticals was written by Revelsky, Igor A.;Chernetsova, Elena S.;Luzyanin, Boris P.;Fedoseeva, Marina V.;Glazkov, Igor N.;Revelsky, Alexander I.. And the article was included in Drug Testing and Analysis in 2010.COA of Formula: C26H26N2O2S This article mentions the following:

Organic elemental anal. (OEA) is an alternative, fast, and relatively inexpensive method for active pharmaceutical ingredient content determination As a result of our research, it was shown that OEA can be used for fast quality control of various pharmaceutical preparations (tablets, capsules, powders, and solutions). It can be concluded that the OEA approach enables fast and accurate determination of active ingredient content and eliminates the need for the use of the reference samples for each active pharmaceutical ingredient. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5COA of Formula: C26H26N2O2S).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.COA of Formula: C26H26N2O2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A facile approach for synthesis of thiazines-, thiazoles- and triazoles-annulated 6-styryl-2-thiouracil derivative was written by Morsy, H. A.;Moustafa, A. H.. And the article was included in Journal of the Iranian Chemical Society in 2020.Application of 3988-77-0 This article mentions the following:

Utility of 4-oxo-6-styryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile I in synthesis of a new series of fused pyrimidines was described. Pyrimido[2,1-b][1,3]thiazines were obtained via Michael addition of compound I to the polarized systems 2-5 in the presence of nanosized ZnO. S-alkylation of pyrimidine I followed by cyclization with phenacyl bromide, monochloroacetic acid, chloroacetonitrile and oxalyl chloride afforded the desired thiazolo[3,2-a]pyrimidines. Hydrazinolysis of compound I followed by addition cyclization with acetic anhydride, formic acid, carbon disulfide and benzoyl chloride afforded triazolo[4,3-a]pyrimidines. The antimicrobial screening showed high activity for thiazolo[3,2-a]pyrimidines II (R = HO) and II (R = H₂N) against both Gram (+ve) and Gram (-ve) bacteria. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Application of 3988-77-0).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Application of 3988-77-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Screening of a model for the distribution of dye in dye-encapsulated silica through the gradual etching of the outermost silica layer using hydrofluoric acid was written by Wi, Rinbok;Lee, Kyoung G.;Yoon, Sun Hong;Lee, Sang Geun;Imran, Muhammad;Kim, Do Hyun. And the article was included in Journal of Nanoscience and Nanotechnology in 2011.Synthetic Route of C26H26N2O2S This article mentions the following:

Monodispersed spherical silica particles emitting blue light were prepared by incorporating 2,5-bis(5-tert-butyl-2-benzoxazolyl)thiophene (BBOT) into a silica matrix. The morphol. and photoluminescent properties were studied to confirm the proper incorporation of BBOT into the silica matrix, using an electron microscope and a fluorescence spectrometer. Four possible models representing the distribution of the dye mols. in a dye-encapsulated silica particle were proposed. To analyze the distribution of the BBOT dye in the BBOT-encapsulated silica, the fluorescent emission intensity was measured while reducing the particle diameter by etching the outermost silica layer with hydrofluoric acid with 0-0.5 weight% concentrations The distribution of BBOT in a silica particle was studied based on the relation between the changes in particle diameter and the changes in emission intensity. The emission intensity of the BBOT-encapsulated silica particle oscillated with the decreasing particle diameter This result supported the multilayered model. Information regarding the distribution of the dye in the silica matrix will provide valuable information for understanding the formation mechanism of dye-encapsulated silica. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5Synthetic Route of C26H26N2O2S).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Synthetic Route of C26H26N2O2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Addition reactions of organic carbanion equivalents via hydrazones in water was written by Wang, Yi-Zhan;Liu, Qi;Cheng, Liang;Yu, Song-Chen;Liu, Li;Li, Chao-Jun. And the article was included in Tetrahedron in 2021.Formula: C13H10OS This article mentions the following:

The addition of organometallic reagents to unsaturated bonds is one of the most powerful tools for carbon-carbon bond formations. Alkylation through organometallic reagents requires stoichiometric quantity of metal and tedious anhydrous operation in most cases. Here, “umpolung” nucleophilic additions of hydrazones to Michael acceptors, carbonyls and imines in water are reported. Under the catalysis of ruthenium(II), the addition reactions could be carried out in pure water to provide various alkylation products in moderate to good yields. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Formula: C13H10OS).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Formula: C13H10OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Transition-Metal-Free Synthesis of C3-Arylated Benzofurans from Benzothiophenes and Phenols was written by Yang, Kevin;Pulis, Alexander P.;Perry, Gregory J. P.;Procter, David J.. And the article was included in Organic Letters in 2018.COA of Formula: C8H5BrS This article mentions the following:

A transition-metal-free synthesis of benzofurans from benzothiophenes and phenols that exploits the unique reactivity of sulfoxides, is reported. Through a sequence involving an interrupted Pummerer reaction and [3,3] sigmatropic rearrangement, phenols can be combined with readily accessible yet synthetically unexplored benzothiophene S-oxides to provide C3-arylated benzofuran products. The products from this approach can undergo subsequent functionalization to gain access to a range of important benzofuran derivatives In the experiment, the researchers used many compounds, for example, 4-Bromobenzo[b]thiophene (cas: 5118-13-8COA of Formula: C8H5BrS).

4-Bromobenzo[b]thiophene (cas: 5118-13-8) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.COA of Formula: C8H5BrS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis and evaluation of small libraries of triazolylmethoxy chalcones, flavanones and 2-aminopyrimidines as inhibitors of mycobacterial FAS-II and PknG was written by Anand, Namrata;Singh, Priyanka;Sharma, Anindra;Tiwari, Sameer;Singh, Vandana;Singh, Diwakar K.;Srivastava, Kishore K.;Singh, B. N.;Tripathi, Rama Pati. And the article was included in Bioorganic & Medicinal Chemistry in 2012.Related Products of 329221-38-7 This article mentions the following:

A synthetic strategy to access small libraries of triazolylmethoxy chalcones 4{1-20}, triazolylmethoxy flavanones 5{1-10} and triazolylmethoxy aminopyrimidines 6{1-17} from a common substrate 4-propargyloxy-2-hydroxy acetophenone using a set of different reactions has been developed. The chalcones and flavanones were screened against mycobacterial FAS-II pathway using a recombinant mycobacterial strain, against which the most potent compound showed ∼88% inhibition in bacterial growth and substantially induction of reporter gene activity at 100 μM concentration The triazolylmethoxy aminopyrimdines were screened against PknG of Mycobacterium tuberculosis displaying moderate to good activity (23-53% inhibition at 100 μM), comparable to the action of a standard inhibitor. In the experiment, the researchers used many compounds, for example, Ax20017 (cas: 329221-38-7Related Products of 329221-38-7).

Ax20017 (cas: 329221-38-7) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Related Products of 329221-38-7

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Functional derivatives of thiophene. X. Synthesis of thieno[2,3-d]pyrimidine and 2,3-polymethylene-4-oxopyrimidine derivatives was written by Shvedov, V. I.;Kharizomenova, I. A.;Grinev, A. N.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1975.Quality Control of 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid This article mentions the following:

Thienopyrimidines [I, R1 = Me, H, R2 = Me, Ph, R1R2 = (CH2)4, n = 1,2,3] were prepared in 40.6-91.2% yields by boiling II (R3 = Et, H) with the appropriate lactam 20 min in dichloroethane containing POCl3. Desulfurization of I gave 48-65.4% III [R4 = CHMeEt, CHMePh, n = 1.2.3]. In the experiment, the researchers used many compounds, for example, 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (cas: 5936-58-3Quality Control of 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid).

2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (cas: 5936-58-3) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Quality Control of 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

DDQ-Catalyzed Direct C(sp³)-H Amination of Alkylheteroarenes: Synthesis of Biheteroarenes under Aerobic and Metal-Free Conditions was written by Song, Chunlan;Dong, Xin;Yi, Hong;Chiang, Chien-Wei;Lei, Aiwen. And the article was included in ACS Catalysis in 2018.Electric Literature of C6H8S This article mentions the following:

A strategy for oxidative Csp³-H/N-H cross-coupling is presented. This reaction successfully utilizes 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and tert-Bu nitrite (TBN) as co-catalysts to construct the biomedical applicable biheteroarenes under aerobic conditions. Notably, this amination reaction is successful with a wide range of alkylheteroarenes and could be used as a functionalization tactic for pharmaceutical research and other areas. Furthermore, preliminary mechanistic studies indicate that the C-N bond formation proceeds through the nucleophilic attack of azole to the carbon cation. In the experiment, the researchers used many compounds, for example, 3-Ethylthiophene (cas: 1795-01-3Electric Literature of C6H8S).

3-Ethylthiophene (cas: 1795-01-3) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Electric Literature of C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Carboxamide-Directed Stereospecific Couplings of Chiral Tertiary Alkyl Halides with Terminal Alkynes was written by Akagawa, Hiroki;Tsuchiya, Naoki;Morinaga, Asuka;Katayama, Yu;Sumimoto, Michinori;Nishikata, Takashi. And the article was included in ACS Catalysis in 2022.HPLC of Formula: 4298-52-6 This article mentions the following:

Herein, the stereospecific Sonogashira coupling of chiral α-halocarboxamides possessing a tert-alkyl moiety R¹R²C(X)(C(O)NHR³) (R¹ = Me, Et; R² = Bu, iso-Bu, Ph, 4-methylphenyl; R³ = Ph, 2,6-diisopropylphenyl, 4-chlorophenyl, etc.; X = Br, Cl) and alkynes R⁴CCH (R⁴ = trimethylsilyl, cyclohexylmethyl, thiophen-3-yl, etc.) was reported. This reaction produces a series of chiral tert-alkylated alkynes R¹R²C(CCR⁴)(C(O)NHR³) in a stereoretentive manner. In this reaction, both the CuBr/bathophen catalyst system and carboxamide directing group are essential for achieving the high enantiospecificities of the couplings. Mechanistic studies of this reaction revealed that the alkynyl copper species is the key intermediate that coordinates to the carboxamide group of chiral α-bromocarboxamide. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6HPLC of Formula: 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.HPLC of Formula: 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem