Day: February 22, 2023

Light-driven post-translational installation of reactive protein side chains was written by Josephson, Brian;Fehl, Charlie;Isenegger, Patrick G.;Nadal, Simon;Wright, Tom H.;Poh, Adeline W. J.;Bower, Ben J.;Giltrap, Andrew M.;Chen, Lifu;Batchelor-McAuley, Christopher;Roper, Grace;Arisa, Oluwatobi;Sap, Jeroen B. I.;Kawamura, Akane;Baldwin, Andrew J.;Mohammed, Shabaz;Compton, Richard G.;Gouverneur, Veronique;Davis, Benjamin G.. And the article was included in Nature (London, United Kingdom) in 2020.Application of 1072-53-3 This article mentions the following:

Post-translational modifications (PTMs) greatly expand the structures and functions of proteins in nature1,2. Although synthetic protein functionalization strategies allow mimicry of PTMs3,4, as well as formation of unnatural protein variants with diverse potential functions, including drug carrying5, tracking, imaging6 and partner crosslinking7, the range of functional groups that can be introduced remains limited. Here we describe the visible-light-driven installation of side chains at dehydroalanine residues in proteins through the formation of carbon-centered radicals that allow C-C bond formation in water. Control of the reaction redox allows site-selective modification with good conversions and reduced protein damage. In situ generation of boronic acid catechol ester derivatives generates RH2C· radicals that form the native (β-CH2-γ-CH2) linkage of natural residues and PTMs, whereas in situ potentiation of pyridylsulfonyl derivatives by Fe(II) generates RF2C· radicals that form equivalent β-CH2-γ-CF2 linkages bearing difluoromethylene labels. These reactions are chem. tolerant and incorporate a wide range of functionalities (more than 50 unique residues/side chains) into diverse protein scaffolds and sites. Initiation can be applied chemoselectively in the presence of sensitive groups in the radical precursors, enabling installation of previously incompatible side chains. The resulting protein function and reactivity are used to install radical precursors for homolytic on-protein radical generation; to study enzyme function with natural, unnatural and CF2-labeled post-translationally modified protein substrates via simultaneous sensing of both chemo- and stereoselectivity; and to create generalized ′alkylator proteins′ with a spectrum of heterolytic covalent-bond-forming activity (i.e., reacting diversely with small mols. at one extreme or selectively with protein targets through good mimicry at the other). Post-translational access to such reactions and chem. groups on proteins could be useful in both revealing and creating protein function. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Application of 1072-53-3).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is also used in the manufacturing of dyes such as thioindigo.Application of 1072-53-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis of novel tetrahydro-3H-benzothieno[2,3-d]imidazoles was written by Johnson, Christopher N.;Martin, Roger T.;Morgan, Helen K.A.;Thompson, Mervyn. And the article was included in Synthetic Communications in 1997.Related Products of 5936-58-3 This article mentions the following:

The synthesis of novel tetrahydro-3H-benzothieno[2,3-d]imidazoles is described. Intramol. cyclization of a key 1,2-diacylaminobenzothiophene was utilized. In the experiment, the researchers used many compounds, for example, 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (cas: 5936-58-3Related Products of 5936-58-3).

2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (cas: 5936-58-3) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Related Products of 5936-58-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Vinylcyclopropane [3+2] Cycloaddition with Acetylenic Sulfones Based on Visible Light Photocatalysis was written by Luque, Adriana;Gross, Jonathan;Zahringer, Till J. B.;Kerzig, Christoph;Opatz, Till. And the article was included in Chemistry – A European Journal in 2022.Recommanded Product: 67237-53-0 This article mentions the following:

The first intermol. visible light [3+2] cycloaddition reaction performed on a meta photocycloadduct employing acetylenic sulfones is described. The developed methodol. exploits the advantages of combining UV and visible-light in a two-step sequence that provides a photogenerated cyclopropane which, through a strain-release process, generates a new cyclopentane ring while significantly increasing the mol. complexity. Mechanistic studies and DFT calculations indicate an energy transfer pathway for the visible light-driven reaction step. This strategy could be extended to simpler vinylcyclopropanes. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0Recommanded Product: 67237-53-0).

3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Recommanded Product: 67237-53-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Iso-anellated thienopyrroles. The chemistry of 5,6-dihydro-4H-thieno[2,3-c]pyrroles and 5H-thieno[2,3-c]pyrroles was written by Feijen, J.;Wynberg, Hans. And the article was included in Recueil des Travaux Chimiques des Pays-Bas in 1970.HPLC of Formula: 28686-90-0 This article mentions the following:

The ring-closure reaction of Me 2,3-bis(chloromethyl)thiophene-5-carboxylate with several primary amines gives a series of 4,6-dihydro-5H-thieno[2,3-c]pyrroles. Oxidation of some of these dihydro compounds, using aqueous H2O2 in methanol, furnishes the corresponding N-oxides. When the N atom possesses an aromatic substituent and the oxidation is carried out with aqueous H2O2 in formic acid, Meisenheimer rearrangement products instead of N-oxides are formed. The structure of one of the Meisenheimer products was elucidated by an independent synthesis of its degradation product. 5H-Thieno[2,3-c]pyrroles, such as I, are prepared by 3 sep. methods: (a) dehydration of the N-oxides; (b) autoxidation of the dihydrothieno[2,3-c]pyrroles; (c) dehydrogenation of the dihydro compounds with chloranil. In the experiment, the researchers used many compounds, for example, Methyl 4-methylthiophene-2-carboxylate (cas: 28686-90-0HPLC of Formula: 28686-90-0).

Methyl 4-methylthiophene-2-carboxylate (cas: 28686-90-0) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.HPLC of Formula: 28686-90-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The Effect of Methyl Acetate, Ethylene Sulfate, and Carbonate Blends on the Parasitic Heat Flow of NMC532/Graphite Lithium Ion Pouch Cells was written by Glazier, S. L.;Li, Jing;Ma, Xiaowei;Ellis, L. D.;Allen, J. P.;Gering, Kevin L.;Dahn, J. R.. And the article was included in Journal of the Electrochemical Society in 2018.SDS of cas: 1072-53-3 This article mentions the following:

The formulation of solvent systems can have a severe impact on the lifetime, rate performance, and temperature performance of lithium ion cells. Me acetate (MA) has been found to increase rate and temperature performance of carbonate solvents, but decreased cell lifetime. This work used ultra-high precision coulometry, in-situ gas anal., and isothermal microcalorimetry to investigate a recently reported promising high rate additive blend of fluoroethylene carbonate (FEC) and 1,3,2-dioxathiolane-2,2-dioxide (DTD) in LiNi_0.5Mn_0.3Co_0.2O₂/graphite pouch cells. Solvent systems composed of blends of ethylene carbonate (EC), Et Me carbonate (EMC), and di-Me carbonate (DMC) were investigated, with additions of 0%, 20% and 40% wt MA. MA was found to decrease the coulombic efficiency and increase slippage, parasitic heat flow, and gas volume The addition of just 1% wt of DTD to 2% FEC improved the performance of cells containing 20% and 40% MA to that of cells containing no MA and 20% MA, resp., under 4.3 V. Results suggest the neg. impact of MA originates from increased electrolyte oxidation at the pos. electrode. Addnl., blends of MA in EC:EMC and EC:DMC (3:7 wt) were tested head-to-head, yielding a small improvement to parasitic heat flow and UHPC performance when cells used EC:EMC. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3SDS of cas: 1072-53-3).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.SDS of cas: 1072-53-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Cinchonidine-Catalyzed Synthesis of Oxazabicyclo[4.2.1]nonanones from N-Aryl-α,β-unsaturated Nitrones and 1-Ethynylnaphthalen-2-ols was written by Wei, Cui;Zhou, Zhou;Pang, Guang-Li;Liang, Cui;Mo, Dong-Liang. And the article was included in Organic Letters in 2022.Synthetic Route of C6H4S This article mentions the following:

A variety of oxazabicyclo[4.2.1]nonanone derivatives, I (R = Ph, naphthalen-2-yl, thiophen-3-yl, pyridin-3-yl, etc., R¹ = Ph, 4-Cl-3-FC₆H₃, furan-2-yl, pyridin-2-yl, etc., R² = H, PhCC, R³ = H, Br, Ar = Ph, 4-F₃CC₆H₄, 3,5-Me₂C₆H₃, naphthalen-2-yl, etc.), was prepared in good yields through a cinchonidine-catalyzed cascade reaction of N-aryl-α,β-unsaturated nitrones R¹CH=CHCH=N(O)Ar and 1-ethynylnaphthalen-2-ols II. Mechanistic studies show that the reaction undergoes a [4+3]-cycloaddition of nitrones to the vinylidene o-quinone methide generated in situ from the 1-ethynylnaphthalen-2-ols in the presence of cinchonidine, 1,3-rearrangement of N-O vinyl moieties, ring-opening, and finally double intramol. cyclizations to afford oxazabicyclo[4.2.1]nonanones I over five steps in a one-pot reaction. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0Synthetic Route of C6H4S).

3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Synthetic Route of C6H4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Intramolecular Kulinkovich-de Meijere reactions of various disubstituted alkenes bearing amide groups was written by Madelaine, Claire;Ouhamou, Nouara;Chiaroni, Angele;Vedrenne, Emeline;Grimaud, Laurence;Six, Yvan. And the article was included in Tetrahedron in 2008.Category: benzothiophene This article mentions the following:

A range of amides fitted with (E) or (Z) disubstituted alkene groups were prepared and evaluated in intramol. Kulinkovich-de Meijere reactions. The corresponding aminocyclopropanes, e.g., I, were obtained with high diastereoselectivity. Good yields could be achieved with substrates bearing suitable substitutions at the olefin moieties. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Category: benzothiophene).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Light-Gated Cobalt(I) Hydride Catalysed Alkyne Hydroboration was written by Bergamaschi, Enrico;Teskey, Christopher J.. And the article was included in Tetrahedron Letters in 2022.Product Details of 67237-53-0 This article mentions the following:

We report a light-gated, catalytic protocol for hydroboration of terminal alkynes based on a bench-stable cobalt(I) hydride complex which undergoes ligand photodissociation with visible light. The products are obtained in good yields and with excellent E-selectivity. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0Product Details of 67237-53-0).

3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Product Details of 67237-53-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization was written by Song, Song;Sun, Xiang;Li, Xinwei;Yuan, Yizhi;Jiao, Ning. And the article was included in Organic Letters in 2015.HPLC of Formula: 1195-14-8 This article mentions the following:

An efficient and practical system for inexpensive bromination and iodination of arenes as well as heteroarenes by using readily available DMSO (DMSO) and HX (X = Br, I) reagents is reported. This mild oxidative system demonstrates a versatile protocol for the synthesis of aryl halides. HX (X = Br, I) are employed as halogenating reagents when combined with DMSO which participates in the present chem. as a mild and inexpensive oxidant. This oxidative system is amenable to late-stage bromination of natural products. The kilogram-scale experiment (>95% yield) shows great potential for industrial application. In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8HPLC of Formula: 1195-14-8).

2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.HPLC of Formula: 1195-14-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Stereolithographic 3D printing with renewable acrylates was written by Voet, Vincent S. D.;Schnelting, Geraldine H. M.;Xu, Jin;Loos, Katja;Folkersma, Rudy;Jager, Jan. And the article was included in Journal of Visualized Experiments in 2018.Safety of 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene This article mentions the following:

The accessibility of cost-competitive renewable materials and their application in additive manufacturing is essential for an efficient biobased economy. We demonstrate the rapid prototyping of sustainable resins using a stereolithog. 3D printer. Resin formulation takes place by straightforward mixing of biobased acrylate monomers and oligomers with a photoinitiatior and optical absorber. Resin viscosity is controlled by the monomer to oligomer ratio and is determined as a function of shear rate by a rheometer with parallel plate geometry. A stereolithog. apparatus charged with the biobased resins is employed to produce complex shaped prototypes with high accuracy. The products require a posttreatment, including alc. rinsing and UV irradiation, to ensure complete curing. The high feature resolution and excellent surface finishing of the prototypes is revealed by SEM. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5Safety of 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Safety of 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem