A facile approach for synthesis of thiazines-, thiazoles- and triazoles-annulated 6-styryl-2-thiouracil derivative was written by Morsy, H. A.;Moustafa, A. H.. And the article was included in Journal of the Iranian Chemical Society in 2020.Application of 3988-77-0 This article mentions the following:
Utility of 4-oxo-6-styryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile I in synthesis of a new series of fused pyrimidines was described. Pyrimido[2,1-b][1,3]thiazines were obtained via Michael addition of compound I to the polarized systems 2-5 in the presence of nanosized ZnO. S-alkylation of pyrimidine I followed by cyclization with phenacyl bromide, monochloroacetic acid, chloroacetonitrile and oxalyl chloride afforded the desired thiazolo[3,2-a]pyrimidines. Hydrazinolysis of compound I followed by addition cyclization with acetic anhydride, formic acid, carbon disulfide and benzoyl chloride afforded triazolo[4,3-a]pyrimidines. The antimicrobial screening showed high activity for thiazolo[3,2-a]pyrimidines II (R = HO) and II (R = H2N) against both Gram (+ve) and Gram (-ve) bacteria. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Application of 3988-77-0).
3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Application of 3988-77-0
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem